The objective of this in vivo pilot study was to investigate whether differential\nbiomarker analysis from skin tape strips could be used, not only to evaluate the difference\nbetween treated and untreated skin, but also to evaluate the effect of different product\ntreatments. Ten volunteers were included in the study, applying two different basic\nformulations on their forearms. After four weeks of product application, and also after one\nweek of treatment remission, tape strips were collected from the different treatment sites,\nas well as from untreated skin. The biomarkers investigated were selected to cover\ndifferent aspects of epidermal differentiation and in connection with moisturization and\nbarrier function. Levels of Involucrin were increased in both treatments, compared to\nuntreated skin, whereas the levels of Keratin-6 were decreased for both treatments. In\naddition, a pattern for increased levels of Hornerin and Claudin-1 was also detected. There\nwere no significant differences between the two treatments, only for treatment compared to\nuntreated, but there were tendencies for different effect on some of the biomarkers\ninvestigated, differences that may reach significance with increased sample size. The major\ndifferences between the two treatments in this study were seen after one week of product\nremission, although due to too small sample size these differences were not significant
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